Prepare the noodles: Bring a large pot of water to boil and cook your pasta according to the package instructions. Drain and set aside.
Cook the Sausage and Ground Beef: While the pasta is boiling, in a large skillet, cook the sausage and ground beef over medium heat until browned. Break the meat into crumbles as it cooks. Once cooked, drain any excess grease.
Add Vegetables: Add the diced yellow onion, red bell pepper, and yellow bell pepper to the skillet. Sauté for about 5-7 minutes until the vegetables are soft and the onion is translucent.
Season: Stir in the onion powder and garlic powder. Mix well to evenly coat the meat and vegetables.
Add Rotel: Pour in the undrained cans of Rotel. Stir to combine with the meat and vegetables.
Melt the Cheese & Milk: Add the cubed Velveeta cheese to the skillet and gradually stir in the milk, mixing until the sauce is creamy and well combined. Reduce the heat to low and stir until the cheese is completely melted and the mixture is smooth.
Combine with Pasta: Add the cooked and drained Rotini pasta to the skillet. Stir everything together until the pasta is well coated with the sauce.
Serve: Serve the Rotel pasta hot, garnished with fresh parsley if desired.